It is possible to switch between Sense UI and the native Android home screen.

"menu>settings>applications>manage applications scroll down to sense and select it then select clear defaults then select clear defaults hit the home key and a pop up will appear. check the box to do this action by default and then select home. Repeat this process (only swap home and sense) to go back to sense. home and sense) to go back to sense."

If you don't check use as default you can switch between them every time you hit the home button.

http://androidforums.com/htc-droid-e...ead-sense.html